Protamine is made from salmon sperm. Usually, the (human) testicles reside across a special barrier from the rest of the body, much like the brain. If this barrier was damaged during a vasectomy, some of the protamine could cross it. The human immune system would then mount an allergic reaction to the non-human sperm proteins.
And for the beauty pageant contestants out there: no, protamine cannot get you pregnant.
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